Nuclear morphometrics and chromatin condensation patterns as disease biomarkers using a mobile microscope
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چکیده
منابع مشابه
Chromatin condensation modulates access and binding of nuclear proteins
The condensation level of chromatin is controlled by epigenetic modifications and associated regulatory factors and changes throughout differentiation and cell cycle progression. To test whether changes of chromatin condensation levels per se affect access and binding of proteins, we used a hypertonic cell treatment. This shift to hyperosmolar medium increased nuclear calcium concentrations and...
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* The work described in this paper was sponsored by the U.S. Atomic Energy Commission. t On leave of absence from the Department of Biochemistry, University College, London. 1 Rabin, B. R., and P. W. Trown, these PROCEEDINGS, 51, 497 (1964). 2 Ellman, G. L., Arch. Biochem. Biophys., 82, 70 (1959). 3Rabin, B. R., D. F. Shaw, N. G. Pon, J. M. Anderson, and M. Calvin, J. Am. Chem. Soc., 80, 2528 (...
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he Cajal body (CB, formerly coiled body) is a prominent nuclear structure, yet its function remains obscure. Now, speculate that the CB is where small nuclear RNAs go for modification. Last year, Kiss's team identified a small guide RNA, U85, that directs both 2'-O-methylation and pseudouridylation of the spliceosomal component U5 snRNA. This year, they've identified six more RNAs, Novel guide ...
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In the past 15 years our perception of nuclear envelope function has evolved perhaps nearly as much as the nuclear envelope itself evolved in the last 3 billion years. Historically viewed as little more than a diffusion barrier between the cytoplasm and the nucleoplasm, the nuclear envelope is now known to have roles in the cell cycle, cytoskeletal stability and cell migration, genome architect...
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As a cell squeezes its nucleus through adjacent tissue, penetrates a basement membrane, or enters a small blood capillary, chromatin density and nuclear factors could in principle be physically perturbed. Here, in cancer cell migration through rigid micropores and in passive pulling into micropipettes, local compaction of chromatin is observed coincident with depletion of mobile factors. Hetero...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2019
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0218757